Transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR)
Example: Treg cell production of IL-10 is essential for regulation of inflammation at environmental interfaces such as the colon and lung, and can enhance the development of functional memory CD8+ T cells during acute lymphocytic choriomeningitis virus (LCMV) infection through suppression of inflammation in the spleen[5]
Dendritic cells
Antigen-presenting cells of the mammalian immune system.
Example: There are multiple pathways by which Treg cell derived IL-10 could modulate the GC response including acting directly on B cells or indirectly through Tfh cells or dendritic cells[5]
ru: Дендритные клетки
IgD
Antibody isotype
Example: While this response appeared similar in the two groups at day 8 p.i., a significant decrease in the percentage and number of B cells with an activated phenotype (IgDlo) and of those cells with a GC phenotype (GL7+CD95+) emerged over time in mice in which Treg cells lacked Il10 expression, with this difference peaking at day 15 p.i.[5]
Il-10
Anti-inflammatory cytokine
Example: Treg cell production of IL-10 is essential for regulation of inflammation at environmental interfaces such as the colon and lung, and can enhance the development of functional memory CD8+ T cells during acute lymphocytic choriomeningitis virus (LCMV) infection through suppression of inflammation in the spleen[5]
Plasmablast
Precursor of a plasma cell
Example: Together, these data indicate that IL-10 specifically produced by Treg cells is important in promoting plasmablast differentiation and the development of the GC following viral infection[5].