Antibodies (immune proteins) that mistakenly target and react with a person's own tissues or organs.
Example: Defective selection can result in the production of autoantibodies and a break in self-tolerance[2].
en: Аутоантитела
Bcl6
A master transcription factor for regulation of T follicular helper cells (TFH cells) proliferation
Example: To study Tfr cells, we specifically deleted the Bcl6 gene in Foxp3+ T reg cells[3].
Germinal center
Transiently formed structures within B cell zone (follicles) in secondary lymphoid organs
Example: T follicular helper (Tfh) cells, a subset of CD4+ T cells characterized by Bcl6 expression, provide essential help to B cells during germinal center (GC) reactions through CD40 and the cytokines IL-21 and IL-4[3].
en: Герминтативный центр
Somatic hypermutation
A process in which point mutations accumulate in the antibody V-regions of both the heavy and light chains
Example: Follicular helper (TFH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation[2].
en: Соматическая гипермутация
T follicular regulatory cells
A subset of regulatory T cells (Treg) that suppress follicular T helper cells (Tfh) and B cells
Example: T follicular regulatory (Tfr) cells offer negative regulation on GC responses[3]