10 Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor terms
DOI: 10.7554/eLife.57544
but also plays important roles ... in a wide variety of physiological and pathological processes
phrase
Example: Adenosine 5’ triphosphate (ATP) is the essential energy currency of intracellular metabolism of all living systems, but also plays important roles as an extracellular signaling molecule in a wide variety of physiological and pathological processes, including neurotransmission (Burnstock, 2007), neuron–glia signaling (Fields and Burnstock, 2006; Khakh and North, 2012), tissue circulation (Cheng et al., 2018; González-Alonso et al., 2002; MacVicar and Newman, 2015), regulation of the immune system (Idzko et al., 2014; Junger, 2011), and cancer development (Di Virgilio et al., 2018; Stagg and Smyth, 2010).
en: но также играет важную роль ... в большом количестве физиологических и патологических процессов
comprehensive
adjective
including or dealing with all or nearly all elements or aspects of something
Example: We prepared a comprehensive set of cysteine-substitution mutants of ATP-binding protein, Bacillus FoF1-ATP synthase ε subunit, labeled with small-molecule fluorophores at the introduced cysteine residue.
en: всесторонний
derived
verb
obtain something from (a specified source)
Example: A molecule derived from ATP is involved in transmitting the pain signals of migraines and severe headaches; and ATP levels can become imbalanced after strokes, when parts of the brain are deprived of blood.
en: получать
elucidate
verb
make (something) clear; explain
Example: In order to elucidate the mechanisms of these processes, an understanding of the spatiotemporal dynamics of ATP is essential.
en: разъяснять
However, these methods do not provide spatial information.
phrase
en: Однако эти методы не предоставляют пространственной информации.
revealed that
phrase
make (previously unknown or secret information) known to others
Example: Screening revealed that the Cy3-labeled glutamine-105 mutant (Q105C-Cy3; designated ATPOS) shows a large fluorescence change in the presence of ATP, with submicromolar affinity, pH-independence, and high selectivity for ATP over ATP metabolites and other nucleotides.
en: показал, что
severe
adjective
(of something bad or undesirable) very great; intense
Example: A molecule derived from ATP is involved in transmitting the pain signals of migraines and severe headaches; and ATP levels can become imbalanced after strokes, when parts of the brain are deprived of blood.
en: тяжелая форма
Some of them have been applied to measure
phrase
Example: Some of them have been applied to measure extracellular ATP concentrations in vivo.
en: Некоторые из них были применены для измерения
spatiotemporal
adjective
belonging to both space and time or to space–time
Example: Here, we describe a method for in-vivo imaging of extracellular ATP with high spatiotemporal resolution.
en: пространственно-временной
stroke
noun
an act of hitting or striking someone or something; a blow
Example: The results confirm that this new sensor is suitable for imaging how ATP signals in the brain, and it may help resolve the underlying mechanisms of migraines and strokes.
