10 Picomolar-sensitive β-amyloid fibril fluorophores by tailoring the hydrophobicity of biannulated π-elongated dioxaborine-dyes terms
https://doi.org/10.1016/j.bioactmat.2021.10.047
aberrant
adjective
diverging from the normal type
Example: Aberrant deposits of amyloid beta (Aβ) peptides are a major pathological hallmark in Alzheimer's disease (AD).
ru: отклоняющийся от нормы
encompass
verb
surround and have or hold within
Example: The cryogenic electron microscopy (cryo-EM) structure of Aβ1-42 was prepared by removing either the Glu22 or Val18 -facing conformation of Phe20, and one entire protofibril was encompassed within the search area (38 × 50 × 32 Å) using AutoDock Vina as the docking software, with an exhaustiveness of 1,000.
ru: охватывать
essential for establishing
phrase
ru: необходимо для создания
excitation
noun
the application of energy to something
Example: To determine the amount of intramolecular charge transfer (ICT) character upon vertical excitation to the first excited state, a calculation based on the differences in electron density was used, and results were analyzed using Multiwfn 3.8.
ru: возбуждение
However, it requires an accurate and reliable visualization method.
phrase
ru: Тем не менее, это требует точного и надежного способа визуализации.
In particular, the strategy of applying ... has successfully offered ...
phrase
Example: In particular, the strategy of applying biannulated π-elongation to electron donor groups has successfully offered significantly lowered Kd values, i.e., higher binding affinity, for Aβ1-42 fibrils.
ru: В частности, стратегия применения ... успешно предложила ...
moiety
noun
a distinct part of a large molecule
Example: The high aqueous solubility that followed from the introduction of this moiety was validated using concentration-dependent absorbance spectra.
ru: фрагмент
prodromal
adjective
relating to or denoting the period between the appearance of initial symptoms and the full development of a rash or fever
Example: Since AD is accompanied by a long prodromal phase of approximately 20 years; aberrant Aβ deposits can be found at least a decade before pathological symptoms, including memory loss, confusion, and cognitive decline of dementia.
ru: продромальный
The maximum absorption wavelength correlated well with the solvent polarizability
phrase
Example: The maximum absorption wavelength correlated well with the solvent polarizability, derived from the solvent-associated electronic stabilization of the Franck-Condon state.
ru: Максимальная длина волны поглощения хорошо коррелировала с поляризуемостью растворителя
This pathology gradually progresses to affect several regions of
phrase
Example: This pathology gradually progresses to affect several regions of the neocortex, hippocampus, as well as cerebrovasculature.
ru: Эта патология постепенно прогрессирует влияя на несколько регионов
